I was in my back yard raking up the grass and after hearing this presentation I was pretty much still for the rest of the day. I think it's spot on for many of us that have been dealing with loss all our lives. Coming to terms with impermanence for me is starting to give me a sense of peace as I learn to live with what is and see my loved ones as an extension of me. Adding to that I am working on seeing others as the same.
Coming to understand these things is a very powerful thing. It makes all that striving to be better, to having more, to finding the secret completely irrelevant. No doubt one's journey is different to another, yet many of us that have had to deal with long terms hardships and extreme loss may come to understand this poem in the same way.
I can say that for me ... accepting change on such a deep level helps me better sit with my discomfort. The sun bites less in summer and feels much warmer in winter.
That's my take. It would be good to hear from others.